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. Author manuscript; available in PMC: 2017 May 19.
Published in final edited form as: Mol Cell. 2016 May 12;62(4):479–490. doi: 10.1016/j.molcel.2016.04.011

Figure 1. Derivation of U2AF35(S34F)-transformed Cell Lines.

Figure 1

(A) Proliferation of parental Ba/F3 cells cultured in the presence (+) or absence (−) of IL-3, and Ba/F3-V, Ba/F3-U2AF35, Ba/F3-U2AF35(S34F) or Ba/F3-BCR-ABL cells cultured in the absence of IL-3. A representative graph from n=9 biological replicates is shown. Two other replicates are shown in Figure S1B.

(B) Proliferation of parental Ba/F3 cells, and established Ba/F3-V, Ba/F3-U2AF35, Ba/F3-U2AF35(S34F) or Ba/F3-BCR-ABL cells.

(C) Tumor formation in mice (n=4 mice per group) injected with Ba/F3-V or Ba/F3-U2AF35(S34F) cells. Error bars indicate SD. *P<0.05; **P<0.01. See also Figure S1.