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. 2016 Aug 20;53(8):5796–5806. doi: 10.1007/s12035-016-0018-9

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Development of amyloid-beta plaques in the hippocampus of APP-PS1 mice at different time points of AD progression. a Amyloid-beta plaques are first observed in the hippocampus of APP-PS1 mice at an age of 4 months and increased in number over time. b The area of Abeta antibody immunoreactive plaques significantly increased in the hippocampus of 13-month-old compared to 10-month-old AD animals. The same increase in amyloid-beta plaque load was observed in the cortex. c Analysis of the GCL volume in the dorsal dentate gyrus of the hippocampus revealed significantly decreased GCL volume specifically in 13-month-old APP-PS1 mice compared to WT (unpaired Student’s t test, p = 0,0213). d With progression of Abeta pathology, amyloid-beta plaques appear in the GCL of the dentate gyrus perforating the healthy tissue structure. Arrows show amyloid-beta plaques stained with Thioflavin S. DAPI was used to stain cell nuclei. Two-way ANOVA with Tukey’s multiple comparisons test (b) and unpaired Student’s t test (c) was performed (n = 3/group). Scale 200 μm (a), 100 μm (d)