Table 1.
Clinical and genotypic characteristics of autopsy subjects by race and APOL1 risk genotype
| Characteristic | White |
African American |
P |
|||
|---|---|---|---|---|---|---|
| 0 risk alleles n = 132 |
0 risk alleles n = 61 |
1 risk allele n = 68 |
2 risk alleles n = 30 |
Racea | AA risk genotype | |
| Age (yr) | 44.2 ± 14.2 | 42.5 ± 12.7 | 42.0 ± 12.2 | 39.9 ± 15.2 | 0.40 | 0.67 |
| Male | 83 (62.9%) | 36 (59.0%) | 37 (54.4%) | 10 (33.3%) | 0.90 | 0.38 |
| BMI (kg/m2) | 30.2 ± 8.4 | 29.4 ± 8.4 | 31.3 ± 12.0 | 27.7 ± 6.8 | 0.98 | 0.22 |
| BMI ≥30 kg/m2 | 53 (40.2%) | 26 (42.6%) | 25 (36.7%) | 6 (20%) | 0.95 | 0.32 |
| Hypertension | 48 (35.6%) | 32 (52.5%) | 41 (60.3%) | 14 (46.7%) | 0.23 | 0.77 |
| Treated hypertension | 19 (14.4%) | 16 (26.2%) | 18 (26.5%) | 6 (20.0%) | 0.15 | 0.85 |
| MAP (mm Hg) | 102.9 ± 13.0 | 108.9 ± 16.0 | 108.3 ± 17.5 | 107.0 ± 16.3 | 0.03 | 0.90 |
| CAD/CVD death | 45 (32.6%) | 19 (31.1%) | 31 (45.6%) | 10 (33.3%) | 0.67 | 0.49 |
| Age CAD/CVD death | 53.1 ± 13.0 | 49.9 ± 10.1 | 41.8 ± 9.7 | 42.9 ± 6.3 | 0.69 | 0.01 |
| Diabetes | 2 (1.5%) | 3 (4.9%) | 4 (5.9%) | 0 (0%) | 1.00 | DNT |
AA, African American; BMI, body mass index; CAD/CVD, coronary artery disease/cerebrovascular disease; DNT, does not test; MAP, mean arterial blood pressure.
a
Race is tested between whites and African Americans with no risk alleles by Wilcoxon rank sum tests for continuous variables and χ2 test for discrete variables (Fisher’s exact test for diabetes). For African Americans APOL1 risk genotype is tested by 3-way analysis of variance for continuous variables and χ2 tests for discrete variables.