Table 4.
Multivariable analysis of microstructural features of arterionephrosclerosis and clinical characteristics
| Model 1: African Americans and whites (both with no risk alleles) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Feature | AA race | Age (yr) | Male sex | BMI | HTN | RxHTN | CAD/CVD | Diabetes |
| Itc | 1.45 | 0.30 | 0.08 | 0.04 | 5.37 | 0.45 | 2.42 | 0.26 |
| –0.40 to 3.31 | 0.21 to 0.39 | –1.68 to 1.84 | –0.14 to 0.05 | 3.11 to 7.63 | –2.13 to 3.02 | 0.37 to 4.47 | –5.02 to 5.53 | |
| 0.12 | <0.001 | 0.93 | 0.40 | <0.001 | 0.73 | 0.02 | 0.92 | |
| Itr | 2.54 | 3.69 | 1.00 | –0.06 | 4.91 | –0.15 | 3.24 | –2.79 |
| 0.67 to 4.43 | 1.99 to 5.39 | –0.77 to 2.79 | –0.17 to 0.05 | 2.63 to 7.19 | –2.78 to 2.48 | 1.14 to 5.35 | –8.13 to 2.54 | |
| 0.01 | <0.001 | 0.26 | 0.26 | <0.001 | 0.91 | 0.01 | 0.30 | |
| Hyaline | 0.29 | 0.08 | –0.27 | –0.21 | 12.8 | –2.09 | 4.98 | 16.5 |
| –4.10 to 4.69 | –0.11 to 0.22 | –4.45 to 3.90 | –0.45 to 0.03 | 7.5 to 18.2 | –8.20 to 4.01 | 0.14 to 9.82 | 4.0 to 28.9 | |
| 0.89 | 0.51 | 0.90 | 0.09 | <0.001 | 0.50 | 0.04 | 0.001 | |
| GS | 1.36 | 0.03 | –0.47 | –0.04 | 2.38 | –0.76 | 0.92 | 2.56 |
| 0.01 to 2.71 | 0.02 to 0.04 | –1.75 to 0.81 | –0.12 to 0.03 | 0.95 to 4.02 | –2.14 to 1.12 | –0.57 to 2.40 | –1.27 to 6.38 | |
| 0.048 | <0.001 | 0.47 | 0.19 | <0.01 | 0.42 | 0.22 | 0.19 | |
| Cort fib | 1.24 | 0.02 | 0.01 | –0.01 | 2.91 | –0.01 | –0.27 | 3.48 |
| –0.25 to 2.74 | 0.01 to 0.03 | –1.40 to 1.42 | –0.09 to 0.07 | 1.11 to 4.72 | –2.09 to 2.08 | –1.92 to 1.38 | –0.75 to 7.72 | |
| 0.10 | <0.001 | 0.99 | 0.82 | 0.01 | 0.99 | 0.75 | 0.11 | |
| Model 2: African Americans | ||||||||
|---|---|---|---|---|---|---|---|---|
| Feature | APOL1 | Age (yr) | Male sex | BMI | MAP | RxHTN | CAD/CVD | Diabetes |
| Itc | 0.58 | 0.31 | –1.45 | –0.12 | 0.23 | –1.46 | 1.07 | NT |
| –0.91 to 2.08 | 0.21 to 0.41 | –3.76 to 0.86 | –0.23 to –0.01 | 0.15 to 0.32 | –4.1 to 1.23 | –1.4 to 3.5 | ||
| 0.44 | <0.001 | 0.22 | 0.03 | <0.001 | 0.39 | 0.39 | ||
| Itr | 1.44 | 0.27 | 0.95 | –0.13 | 0.27 | –2.91 | 1.90 | NT |
| –0.24 to 3.12 | 0.16 to 0.390 | –1.65 to 3.56 | –0.25 to 0.007 | 0.18 to 0.37 | –5.95 to 0.13 | –1.07 to 4.5 | ||
| 0.09 | <0.001 | 0.47 | 0.04 | <0.001 | 0.06 | 0.23 | ||
| Hyaline | –1.12 | 0.10 | –0.68 | –0.31 | 0.48 | –3.74 | 3.37 | NT |
| –4.3 to 2.0 | –0.11 to 0.31 | –5.5 to 4.2 | –0.53 to –0.07 | 0.31 to 0.66 | –9.4 to 2.0 | –1.9 to 8.6 | ||
| 0.48 | 0.37 | 0.78 | 0.01 | <0.001 | 0.20 | 0.20 | ||
| GS | 0.16 | 0.15 | –0.37 | –0.04 | 0.11 | –2.23 | –0.64 | NT |
| –0.98 to 1.3 | 0.07 to 0.22 | –2.1 to 1.4 | –0.13 to 0.04 | 0.04 to 0.17 | –4.29 to –0.17 | –2.5 to 1.2 | ||
| 0.78 | <0.001 | 0.68 | 0.29 | 0.001 | 0.03 | 0.50 | ||
| Cort fib | 0.46 | 0.10 | –0.52 | –0.09 | 0.19 | –2.38 | –2.05 | NT |
| –0.99 to 1.91 | 0.004 to 0.19 | –2.7 to 1.7 | –0.20 to 0.01 | 0.11 to 0.27 | –4.99 to 0.24 | –4.45 to 0.35 | ||
| 0.53 | 0.04 | 0.65 | 0.09 | <0.001 | 0.08 | 0.09 | ||
Correlation coefficients derived from fractional polynomials of untransformed data. Within the cells, the upper values are correlation coefficients with 95% confidence intervals and the lower values are P values. Significant values are in bold.
AA, African American; APOL1, genotype designated as 0, 1, and 2 risk alleles; BMI, body mass index (kg/m2); CAD/CVD, coronary artery disease/cerebrovascular disease; Cort fib, cortical fibrosis; GS, glomerulosclerosis; HTN, hypertension; Itc, intimal thickening of arcuate arteries as a percentage of the outer diameter of the artery wall; Itr, intimal thickening of interlobular arteries as a percentage of the outer diameter of the artery wall; MAP, mean arterial pressure (mm Hg); NT, not tested, no African Americans with diabetes and 2 risk alleles; RxHTN, treated hypertension.