Table 5.
Multivariable analyses of arteriosclerosis versus mean arterial blood pressure comparing race and APOL1 risk genotype
| African American and white | ||||
|---|---|---|---|---|
| Risk genotype | Coeff. (95% CI) | P | Coeff. (95% CI) | P |
| 0 risk alleles | Itc | Itc transformed | ||
| MAP | 0.34 (0.25 to 0.42) | <0.001 | 0.007 (0.005 to 0.008) | <0.001 |
| African American | –0.11 (–2.62 to 2.40) | 0.93 | –0.008 (–0.059 to 0.043) | 0.74 |
| 0 risk alleles | Itr | Itr transformed | ||
| MAP | 0.31 (0.23 to 0.39) | <0.001 | 0.007 (0.005 to 0.009) | <0.001 |
| African American | 0.64 (–1.75 to 3.04) | 0.60 | 0.009 (–0.043 to 0.062) | 0.71 |
| 0 risk alleles | Hyaline | Hyaline transformed | ||
| MAP | 0.65 (0.45 to 0.84) | <0.001 | 0.011 (0.008 to 0.014) | <0.001 |
| African American | –4.37 (–10.06 to 1.31) | 0.13 | –0.64 (–0.151 to 0.023) | 0.15 |
| African Americans | ||||
| Itc vs. MAP | Itc transformed vs. MAP | |||
| 0 risk alleles | 0.34 (0.25 to 0.42) | <0.001 | 0.007 (0.005 to 0.008) | <0.001 |
| 1 risk allele | 0.20 (0.10 to 0.30) | <0.001 | 0.004 (0.002 to 0.006) | <0.001 |
| 2 risk alleles | 0.45 (0.22 to 0.69) | 0.001 | 0.007 (0.003 to 0.011) | 0.001 |
| Itr vs. MAP | Itr transformed vs. MAP | |||
| 0 risk alleles | 0.32 (0.24 to 0.40) | <0.001 | 0.007 (0.004 to 0.009) | <0.001 |
| 1 risk allele | 0.22 (0.11 to 0.33) | <0.001 | 0.004 (0.002 to 0.007) | 0.001 |
| 2 risk alleles | 0.56 (0.28 to 0.85) | <0.001 | 0.010 (0.005 to 0.014) | <0.001 |
| Hyaline vs. MAP | Hyaline transformed | |||
| 0 risk alleles | 0.62 (0.43 to 0.81) | <0.001 | 0.010 (0.008 to 0.014) | <0.001 |
| 1 risk allele | 0.41 (0.18 to 0.64) | 0.001 | 0.007 (0.003 to 0.012) | 0.001 |
| 2 risk alleles | 0.14 (0.03 to 0.24) | 0.013 | 0.007 (0.001 to 0.012) | 0.017 |
Correlation coefficients derived from fractional polynomial regressions for untransformed and linear regression for transformed data. Number of subjects with mean arterial blood pressure: 0 risk alleles: white, n = 65; African American, n = 45. 1 risk allele: African American, 46; 2 risk alleles: African American, 22.
CI, confidence interval; Itc, intimal thickening of arcuate arteries as a percentage of the outer diameter of the artery wall; Itr, intimal thickening of interlobular arteries as a percentage of the outer diameter of the artery wall; MAP, mean arterial blood pressure (mm Hg).