Table 7.
Multivariable analyses of Itr versus mean arterial blood pressure and treatment of hypertension by APOL1 risk genotype in African Americans ≥35 years old
| Characteristic | Itr | Itr transformed | ||
|---|---|---|---|---|
| 2 risk alleles, n = 14 | Coeff. (95% CI) | P | Coeff. (95% CI) | P |
| MAP (mm Hg) | 0.59 (0.16 to 1.01) | 0.012 | 0.007 (0.002 to 0.013) | 0.016 |
| RxHTN, n = 4 | –14.30 (–29.0 to –0.55) | 0.043 | –0.19 (–0.37 to 0.01) | 0.041 |
| α = 0.05:854 normality = 0.81 |
α = 0.05:832 normality = 0.66 |
|||
| 1 risk allele, n = 35 | ||||
| MAP (mm Hg) | 0.21 (0.05 to 0.36) | 0.012 | 0.004 (0.001 to 0.007) | 0.017 |
| RxHTN, n = 13 | –0.81 (–6.4 to 4.7) | 0.77 | –0.033 (–0.15 to 0.08) | 0.57 |
| α = 0.05:791 normality = 0.13 |
α = 0.05:713 normality = 0.42 |
|||
| 0 risk alleles, n = 37 | ||||
| MAP (mm Hg) | 0.27 (0.11 to 0.44) | <0.01 | 0.005 (0.002 to 0.009) | <0.01 |
| RxHTN, n = 11 | –0.17 (–5.6 to 5.3) | 0.95 | 0.007 (–0.10 to 0.12) | 0.89 |
| α = 0.05:914 normality = 0.04 |
α = 0.05:920 normality = 0.31 |
|||
Linear regressions are shown with α and normality tests. Significant P values for treatment effect are in bold.
Itr, % intimal thickening of interlobular arteries; Itr transformed, log10 (Itr + 10); MAP, mean arterial blood pressure; RxHTN, treatment of hypertension.