TABLE 3.
Meta-analysis of Malignant Upgrade Rate of NCB-confirmed RS at Surgical Excision
| Needle Gauge (G) | No. Cores (Mean) | Total Cases (N) | Upgrade Rate of RS Without Atypia on CNB (n [%]) | Carcinoma Type in Upgraded Cases | Upgrade Rate of CNB RS With Atypia | Carcinoma Type in Upgraded Cases | Overall Upgrade Rate of RS on CNB (n [%]) | |
|---|---|---|---|---|---|---|---|---|
| Jackman et al6 | 14 | 10 | 5 | 2/5 (40) | 1 DCIS, 1 IDC | NA | NA | 2/5 (40) |
| Kirwan et al28 | 14 | 9.5 | 34 | 0/34 (0) | NIL | NA | NA | 0/34 (0) |
| Philpotts et al23 | 14, 11 | 9 | 8 | 0/7 (0) | NIL | 0/1 (0) | NIL | 0/8 (0) |
| Brenner et al29 | 14, 12, 11 | NS | 103 | 5/74 (7) | 3 DCIS, 2 IDC | 8/29 (28) | 5 DCIS, 3 IDC | 13/103 (13) |
| Brodie et al30 | 14 | 4 | 16 | 2/16 (13) | 2 DCIS | NA | NA | 2/16 (13) |
| Cawson et al31 | 14 | 6 | 54 | 0/27 (0) | NIL | 3/27 (11) | 3 DCIS | 3/54 (6) |
| Lee et al32 | NS | NS | 32 | 1/23 (4) | 1 DCIS | 4/9 (44) | 3 DCIS, 1 IDC | 5/32 (16) |
| Dillon et al33 | 16, 14, 11 | NS | 63 | 2/41 (5) | 2 DCIS | 7/22 (32) | 6 DCIS, 1 IDC | 9/63 (14) |
| Lopez-Medina et al34 | 14 | 6.4 | 43 | 6/38 (16) | 1 DCIS, 3 TC, 2 IDC | 2/5 (40) | 1 DCIS, 1 TC | 8/43 (19) |
| Lieske et al35 | 14 | 5 | 43 | 4/43 (9) | NS | NA | NA | 4/43 (9) |
| Hayes et al36 | NS | NS | 57 | 4/42 (10) | 4 DCIS | 3/15 (20) | 3 DCIS | 7/57 (12) |
| El-Sayed et al37 | NS | NS | 153 | 12/132 (9) | 6 DCIS, 6 IC | 5/21 (24) | 1 DCIS, 4 IC | 17/153 (11) |
| Resetkova et al7 | 11, 9 | 10 | 19 | 0/10 (0) | NIL | 0/9 (0) | NIL | 0/19 (0) |
| Rajan et al38 | 14 | 6 | 25 | 1/22 (5) | 1 DCIS | 0/3 (0) | NIL | 1/25 (4) |
| Linda et al24 | 14, 11 | 7 | 65 | 5/62 (8) | 3 DCIS, 1 IDC, 1 ILC | 0/3 (0) | NIL | 5/65 (8) |
| Rakha et al39 | NS | NS | 329 | 25/278 (9) | 14 DCIS, 5 TC, 2 ILC, 4 IC | 20/51 (39) | 12 DCIS, 8 IC | 45/329 (13.7) |
| Rakha et al40 | NS | NS | 42 | 1/39 (3) | 1 IDC | 0/3 (0) | NIL | 1/42 (24) |
| Bianchi et al41* | 14 | 4 | 49 | 4/49 (8) | 3 DCIS, 1 ILC | NA | NA | 4/49 (8) |
| Andacoglu et al25 | 11, 9 | 7.6 | 67 | 4/67 (6) | 4 DCIS | NA | NA | 4/67 (6) |
| This study | 11, 9 | 8 | 48 | 1/48 (2) | 1 DCIS | NA | NA | 1/48 (2) |
| Total | 7 | 1255 | 79/1057 (7.5) | 46 DCIS, 7 IDC, 8 TC, 4 ILC, 10 IC, 4 N/S | 52/198 (26) | 34 DCIS, 5 IDC, 1 TC, 12 IC | 131/1255 (10.4) |
*
This paper excluded all cases with synchronous ipsilateral DCIS or invasive carcinoma.
IC indicates invasive carcinoma, not otherwise specified; IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma; NA, not applicable; NS, not specified; TC, tubular carcinoma.