Table 2. Height, BMI at age 18 and Risk of Breast Cancer According to Molecular Subtype, Nurses’ Health Study and Nurses’ Health Study II.
| Luminal A | Luminal B | HER2-enriched | Basal-like | Unclassified | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | HR (95% CI) | Cases | HR (95% CI) | Cases | HR (95% CI) | Cases | HR (95% CI) | Cases | HR (95% CI) | p-het | |
| Height (inches)a,b | 0.78 | ||||||||||
| ≤62 | 539 | 1.00 (reference) | 243 | 1.00 (reference) | 71 | 1.00 (reference) | 71 | 1.00 (reference) | 20 | 1.00 (reference) | |
| 63 | 342 | 1.19 (1.04–1.37) | 137 | 1.00 (0.81–1.24) | 32 | 0.94 (0.62, 1.43) | 44 | 1.17 (0.80, 1.71) | 17 | 1.67 (0.87, 3.20) | |
| 64 | 515 | 1.32 (1.17–1.50) | 234 | 1.21 (1.00–1.45) | 39 | 0.85 (0.57, 1.27) | 76 | 1.50 (1.08, 2.09) | 19 | 1.38 (0.73, 2.60) | |
| 65 | 450 | 1.41 (1.24–1.60) | 167 | 1.05 (0.86–1.29) | 52 | 1.41 (0.97, 2.05) | 61 | 1.47 (1.04, 2.09) | 16 | 1.38 (0.70, 2.70) | |
| 66 | 452 | 1.45 (1.27–1.65) | 198 | 1.20 (0.99–1.46) | 56 | 1.65 (1.14, 2.39) | 63 | 1.58 (1.11, 2.25) | 25 | 2.20 (1.19, 4.08) | |
| ≥ 67 | 685 | 1.52 (1.34–1.73) | 302 | 1.19 (0.98–1.43) | 68 | 1.48 (1.02, 2.15) | 93 | 1.59 (1.13, 2.24) | 31 | 2.00 (1.08, 3.70) | |
| HR per 1 inch increase |
2983 | 1.07 (1.05, 1.08) | 1281 | 1.02 (1.00, 1.05) | 318 | 1.08 (1.02, 1.13) | 408 | 1.07 (1.02, 1.11) | 128 | 1.10 (1.02, 1.19) | |
| P trend | <0.0001 | 0.05 | 0.004 | 0.004 | 0.02 | ||||||
|
BMI at age 18
(kg/m2)a |
0.001 | ||||||||||
| <18.5 | 373 | 1.10 (0.98–1.25) | 136 | 0.83 (0.68, 1.01) | 52 | 1.77 (1.24, 2.53) | 52 | 1.35 (0.96, 1.90) | 20 | 2.00 (1.11, 3.61) | |
| 18.5-20.0 | 593 | 1.05 (0.95–1.16) | 258 | 0.95 (0.81, 1.11) | 84 | 1.75 (1.28, 2.38) | 93 | 1.46 (1.10, 1.94) | 22 | 1.37 (0.78, 2.42) | |
| 20-21.9 | 922 | 1.0 (reference) | 419 | 1.00 (reference) | 79 | 1.00 (reference) | 101 | 1.00 (reference) | 27 | 1.00 (reference) | |
| 22.0-24.9 | 492 | 0.89 (0.79–0.99) | 223 | 0.88 (0.74, 1.03) | 47 | 0.96 (0.67, 1.38) | 79 | 1.29 (0.96, 1.73) | 25 | 1.51 (0.87, 2.60) | |
| ≥ 25 | 205 | 0.79 (0.68–0.92) | 82 | 0.69 (0.54, 0.87) | 11 | 0.48 (0.26, 0.91) | 17 | 0.61 (0.36, 1.02) | 9 | 1.11 (0.52, 2.38) | |
| HR per 1 kg/m2 increase |
2585 | 0.96 (0.95, 0.98) | 1118 | 0.98 (0.96, 1.00) | 201 | 0.88 (0.83, 0.92) | 342 | 0.94 (0.90, 0.98) | 103 | 0.95 (0.88, 1.02) | |
| P trend | <0.0001 | 0.10 | <0.0001 | 0.008 | 0.29 |
a
Models adjusted for age (months), time period, cohort, recent alcohol consumption (continuous), age at menarche (<12, 12, 13, 14, >14), age at menopause (years), menopausal status and PMH use (premenopausal, postmenopausal-never PMH, postmenopausal-past PMH, postmenopausal-current PMH, postmenopausal –unknown PMH), birth index (cont), history of benign breast disease (yes/no), first degree family history of breast cancer (yes/no), birth weight (< 5.5 lbs, 5.5-6.9 lbs, 7-8.4 lbs, ≥ 8.5 lbs), weight at age 18 (kg), weight change since age 18 (kg), interaction between menopausal status and weight change since 18, cumulative average physical activity (quintiles).
b
Model for height also adjusted for weight at age 18 (in kg)