Table 2. IPA analyses of the top networks and predicted canonical pathways associated to the significantly altered expression genes in HepG2 cells in response to BLE treatment.

Top network	Score
1. Cancer, Cell Death and Survival, Cellular Movement	44
2. Cancer, Cardiac Dilation, Cardiovascular System Development and Function	32
3. Cell Cycle, Connective Tissue Development and Function, Cellular Development	27
4. Metabolic Disease, Drug Metabolism, Endocrine System Development and Function	25
5. Behavior, Cell-To-Cell Signaling and Interaction, Drug Metabolism	21

Notes.

The analyses were based on the significantly regulated (p < 0.05) genes of BLE treatment (138 genes). BLE, leaf water extract of B. racemosa; VDR, vitamin D receptor; RXR, retinoic X receptor; TR, thyroid hormone receptor; PXR, pregnane X receptor.