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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Mol Cell. 2016 Sep 1;63(5):729–738. doi: 10.1016/j.molcel.2016.08.004

Figure 1. Models to study DSB-induced aging.

Figure 1

Two methods to induce clean DSBs provide tools to dissect the age-related consequences stemming from DSBs alone. The first method induces DSBs via adenoviral delivery of a restriction enzyme, SacI, which is under control of tetracycline and tamoxifen (White et al., 2015). The second method, a transgenic mouse model, induces DSBs conditionally using the I-PpoI restriction enzyme fused to GFP under control of tamoxifen, and in a tissue-specific manner using Cre recombinase (Kim et al., 2015).