Skip to main content
. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Mol Cell. 2016 Sep 1;63(5):729–738. doi: 10.1016/j.molcel.2016.08.004

Figure 2. DNA double-strand breaks (DSBs), cellular consequences, and the pathways leading to aging.

Figure 2

DSBs, arising endogenously or exogenously, activate the DDR that directs cells to repair the break, enter apoptosis, or undergo cellular senescence. The resulting molecular and cellular end points can cause the physiologically detrimental consequences over time leading to the overall decline of an organism, ultimately resulting in disease and death.