Table 2.
Hemodynamic Characteristics
| PH Patients (n = 53) | Severe PH (n = 13) | CHD (n = 33) | No CHD (n = 20) | CHD P value | Shunt (n = 21) | No Shunt (n = 32) | Shunt P value | |
|---|---|---|---|---|---|---|---|---|
| MPAP, mm Hg | 33.0 (25.0 - 43.0) | 60.0 (46.0 - 61.0) | 40.5 (28.0 - 52.0) | 27.0 (23.0 - 31.0) | 0.0074* | 41.5 (32.0 - 54.0) | 28.5 (20.5 - 38.5) | 0.0082* |
| MAP, mm Hg | 58.0 (55.0 - 63.0) | 58.0 (52.0 - 60.0) | 59.0 (53.0 - 63.0) | 57.0 (55.0 - 63.0) | 0.77 | 57.5 (52.5 - 61.0) | 59.5 (55.0 - 63.0) | 0.26 |
| MPAP/MAP | 0.59 (0.43 - 0.79) | 1.00 (0.81 - 1.04) | 0.66 (0.42 - 0.94) | 0.44 (0.39 - 0.56) | 0.0086* | 0.71 (0.59 - 0.97) | 0.46 (0.35 - 0.61) | 0.003* |
| SPAP, mm Hg | 52.0 (38.0 - 63.0) | 84.0 (63.0 - 90.0) | 58.0 (39.0 - 67.0) | 41.0 (35.0 - 52.0) | 0.0134* | 60.5 (52.0 - 73.0) | 43.0 (34.0 - 56.0) | 0.0068* |
| DPAP, mm Hg | 23.0 (15.0 - 32.0) | 42.0 (33.0 - 46.0) | 27.0 (14.0 - 35.0) | 19.0 (15.0 - 22.0) | 0.035* | 29.5 (22.0 - 36.0) | 19.5 (14.0 - 27.0) | 0.0186* |
| TPG, mm Hg | 23.0 (16.0 - 35.0) | 51.0 (38.0 - 54.0) | 30.0 (19.0 - 43.0) | 17.0 (15.0 - 22.0) | 0.0029* | 33.0 (22.0 - 48.0) | 18.5 (13.5 - 29.0) | 0.0035* |
| DTPG, mm Hg | 13.0 (6.0 - 26.0) | 35.0 (26.0 - 39.0) | 16.5 (5.0 - 27.0) | 10.0 (6.0 - 12.0) | 0.0087* | 21.5 (13.0 - 28.0) | 11.0 (5.0 - 16.0) | 0.0069* |
| MLAP, mm Hg | 8.5 (7.0 - 10.0) | 7.0 (6.0 - 8.0) | 8.0 (6.0 - 10.0) | 8.8 (7.3 - 10.5) | 0.29 | 7.5 (6.0 - 9.0) | 9.0 (7.0 - 10.0) | 0.17 |
| MRAP, mm Hg | 7.0 (5.0 - 8.0) | 7.0 (5.0 - 9.0) | 7.0 (5.0 - 8.0) | 5.5 (5.0 - 7.5) | 0.35 | 7.0 (5.0 - 7.0) | 6.0 (5.0 - 8.0) | 0.96 |
| RVEDP, mm Hg | 8.0 (6.0 - 10.0) | 9.0 (6.0 - 11.0) | 8.6 (7.0 - 10.2) | 7.0 (5.1 - 8.6) | 0.05 | 9.0 (7.0 - 9.9) | 7.0 (6.0 - 9.1) | 0.18 |
| CI, L/min/m2 | 3.38 (2.98 - 3.82) | 3.52 (3.23 - 3.98) | 3.23 (2.94 - 3.98) | 3.42 (3.00 - 3.68) | 0.93 | 3.23 (3.03 - 3.63) | 3.38 (2.84 - 3.82) | 0.95 |
| Qp/Qs | 1.00 (1.00 - 1.00) | 1.00 (0.93 - 1.00) | 1.00 (1.00 - 1.19) | 1.00 (1.00 - 1.00) | 0.09 | 1.16 (1.00 - 1.55)† | 1.00 (1.00 - 1.00) | 0.0043* |
| PVRi, WU·m2 | 6.79 (4.10 - 10.89) | 15.8 (11.7 - 19.1) | 7.64 (4.81 - 13.89) | 5.33 (3.48 - 6.96) | 0.07 | 7.67 (5.57 - 14.09) | 5.60 (3.21 - 8.70) | 0.08 |
| PVR/SVR | 0.37 (0.25 - 0.60) | 0.85 (0.77 - 1.12) | 0.49 (0.23 - 0.69) | 0.33 (0.25 - 0.38) | 0.22 | 0.49 (0.26 - 0.77) | 0.34 (0.25 - 0.53) | 0.29 |
Presented as n (%) or median (interquartile range). PH indicates pulmonary hypertension; CHD, congenital heart disease; MPAP; mean pulmonary arterial pressure; MAP, mean (systemic) arterial pressure; SPAP, systolic pulmonary arterial pressure; DPAP, diastolic pulmonary arterial pressure; MLAP, mean left atrial pressure or pulmonary capillary wedge pressure; MRAP, mean right atrial pressure; CI, cardiac index; Qp/Qs, ratio of pulmonary-to-systemic blood flow; PVRi, indexed pulmonary vascular resistance; SVR, systemic vascular resistance.
P<0.05.
Four patients had a net right-to-left shunt (Qp:Qs of 0.94, 0.86, 0.89, 0.93). CHD and Shunt P values represent comparison between those without/with CHD and a shunt, respectively.