Table 1. Dengue virus serotype 2 (DENV-2) recombinant strains obtained using RDP4 package.
A total of 26 recombinant strains were identified using RDP4 with p-value < 0.00001. The breakpoint positions are reported according to the position in the respective recombinant sequence. The recombination is detected using at least two of the six recombination detection methods in RDP4 program namely RDP, GENCONV, BOOTSCAN, MAXCHI, CHIMAERA, SISCAN and 3SEQ and are represented as R, G, B, M, C, S and Q, respectively. The method showing comparatively lowest p-value is shown and is represented as bold and the corresponding p-value is also reported.
Serial number | Recombinant DENV-2 strain [Genotype_ GenBank-Accession] | Major Parent [Genotype_ GenBank-Accession] | Minor Parent [Genotype_ GenBank-Accession] | Breakpoint start | Breakpoint end | Methods: RGBMCSQ | Lowest p-value |
---|---|---|---|---|---|---|---|
1 | AM_GQ398257 | AM_GQ868600 | AA_GQ398269 | 4,256 | 6,361 | RGBMCSQ | 3.70E−140 |
2 | AM_JQ922552 | AM_JQ922550 | AM_JQ922549 | 6,081 | 6,535 | RGBMCS | 1.05E−20 |
3 | AM_JQ922553 | AM_JQ922552 | C_JQ922551 | 7,448 | 8,410 | RGBMCSQ | 1.97E−36 |
4 | AM_JQ922550 | AM_JQ922552 | C_JQ922551 | 7,448 | 8,410 | RGBMCSQ | 1.97E−36 |
5 | AM_AF100467 | AM_EU056811 | AM_GQ868588 | 6,000 | 7,947 | RGBQ | 1.23E−18 |
6 | C_EU179859 | C_EU482640 | Unknown | 2,985 | 3,975 | RGBMCSQ | 3.56E−84 |
7 | C_FJ196854 | C_JN851128 | A1_FJ196851 | 0* | 773 | RGBS | 1.89E−28 |
C_GQ398264 | A1_FJ196851 | 10,200 | 10,498* | RGB | 1.55E−14 | ||
8 | C_ JQ922551 | C_GQ398261 | AM_JQ922552 | 1,544 | 1,824 | RGB | 5.428E−08 |
9 | AA_GQ398269 | AA_GQ398300 | AAF204178 | 4,289 | 6,204 | RGBMCS | 4.51E−53 |
10 | AA_JN819408 | AA_GQ868553 | Unknown | 10,411 | 10,620* | RGBMC | 1.41E−69 |
11 | AA_EU482726 | AA_EU596491 | AA_EU482719 | 5,260 | 8,059 | GBMCS | 1.22E−38 |
12 | AA_JF357906 | AA_EU621672 | Unknown | 10,466 | 10,783* | RGBMCQ | 1.60E−113 |
13 | AA_FJ744708 | AA_JF357906 | Unknown | 7,502 | 7,567 | RB | 2.97E−08 |
14 | AA_JN819418 | AA_M20558 | Unknown | 10,266 | 10,576* | RGBMC | 8.77E−78 |
15 | AA_AF100466 | AA_GQ868540 | A1_AF100463 | 0* | 606 | RGBSQ | 6.77E−40 |
16 | AI_FJ196851 | AI_GQ868545 | C_FJ196852 | 4,984 | 5,266 | RGB | 1.82E−22 |
AI_GQ868545 | C_FJ196853 | 8,294 | 9,438 | RGBMCSQ | 3.33E−44 | ||
17 | AI_FJ687444 | AI_FJ744721 | Unknown | 10,277 | 10,363* | RGB | 6.92E−27 |
18 | AI_EU482784 | AI_EU482775 | C_EU482640 | 2,726 | 3,751 | RGBMCSQ | 8.50E−73 |
AI_FM210211 | Unknown | 9,970 | 10,679* | RGBMC | 1.59E−19 | ||
19 | AI_FJ410193 | AI_FM210211 | Unknown | 0* | 59 | RGB | 2.79E−08 |
20 | AI_FM210211 | AI_FJ687444 | AA_EU482783 | 9,988 | 10,691* | RGBMCS | 3.04E−29 |
21 | AI_GU131924 | AI_FM210211 | Unknown | 9,955 | 10,557* | RGBMC | 1.59E−19 |
22 | AI_JN368476 | AI_GU131930 | AI_GU131897 | 8,188 | 9,896 | RGBS | 1.14E−12 |
23 | AI_FJ639717 | Unknown | AI_GU131897 | 8,317 | 9,306* | RGBSQ | 1.14E−12 |
24 | AI_JF730047 | Unknown | AI_GU131897 | 8,329 | 9,318* | RGBSQ | 1.14E−12 |
25 | AI_GU131930 | Unknown | AI_GU131897 | 8,317 | 9,306* | RGBSQ | 1.14E−12 |
26 | AI_JF730048 | Unknown | AI_GU131897 | 8,328 | 9,317 | RGBSQ | 1.14E−12 |
Notes.
Indicates that the actual breakpoint position is undetermined in subsequent recombination event.