Table 2.
COL5A1 Targeting miRNAs Conserved among Mammals and Their P Values between IPF and Control Groups
| miRNA | Conserved sites |
Poorly conserved sites |
Total context score | P value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Total | 8mer | 7mer-m8 | 7mer-1A | Total | 8mer | 7mer-m8 | 7mer-1A | |||
| miR-185-5p | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | −0.08 | 0.005* |
| miR-186-5p | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | −0.07 | 0.006* |
| miR-4306 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | −0.08 | 0.057 |
| miR-495-5p | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | −0.02 | 0.111 |
| miR-379-5p | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | −0.05 | 0.115 |
| miR-335-5p | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | −0.08 | 0.145 |
| miR-4644 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | −0.08 | 0.186 |
| miR-874-3p | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | −0.04 | 0.190 |
| miR-491-5p | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | −0.11 | 0.198 |
| miR-488-5p | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | −0.01 | 0.198 |
| miR-125a-3p | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | −0.10 | 0.229 |
| miR-874-5p | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | −0.04 | 0.247 |
| miR-495-3p | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | −0.02 | 0.408 |
| miR-3529 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | −0.05 | 0.431 |
| miR-542-3p | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | −0.13 | 0.431 |
| miR-590-3p | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | −0.03 | 0.533 |
| miR-379-3p | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | −0.05 | 0.645 |
| miR-544a | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | −0.37 | 0.661 |
| miR-543 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | −0.03 | 0.765 |
| miR-539-5p | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | −0.03 | 0.859 |
| miR-873-3p | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | −0.10 | 0.924 |
| miR-873-5p | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | −0.10 | 0.956 |
| miR-1193-5p | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | −0.05 | 0.959 |
*P < 0.05, compared to the control group.
IPF, idiopathic pulmonary fibrosis.