Table 2.
BP, body water, and serum electrolyte levels
Characteristic | Inpatient Cohort: Baselinea | Outpatient Cohort: Tenapanor | Outpatient Cohort: Placebo | |||
---|---|---|---|---|---|---|
Tenapanor, n=8 | Placebo, n=8 | Baseline,a n=37 | Change from Baseline to End of Treatment,b n=35 | Baseline,a n=35 | Change from Baseline to End of Treatment,b n=34 | |
Predialysis SBP, mmHg | 156.0±17.1 | 145.1±23.9 | 142.9±25.6 | −1.1±24.6c | 148.4±22.7 | −1.3±22.9 |
Predialysis DBP, mmHg | 86.5±7.9 | 77.3±16.1 | 76.8±13.8 | −1.6±10.7c | 81.6±16.2 | −0.1±11.2 |
Total body water, L | 48.0±14.7 | 50.1±16.8 | 47.4±10.5d | 0.3±5.6e | 46.9±13.8c | 1.9±5.8f |
Extracellular water, L | 22.3±8.1 | 22.7±6.8 | 22.4±4.8d | 0.0±2.9e | 21.7±6.2c | 0.7±3.2f |
Calcium, mg/dlg | 8.9±0.6 | 9.3±0.7 | 8.9±0.6 | 0.2±0.7 | 8.7±0.6 | 0.0±0.7 |
Potassium, mEq/Lg | 4.8±0.5 | 4.9±0.5 | 5.0±0.6 | −0.1±0.8 | 5.4±1.0 | −0.2±0.6 |
Sodium, mEq/Lg | 136.0±3.1 | 136.4±3.0 | 135.0±3.7 | −0.8±3.6 | 135.5±2.5 | 0.3±2.7 |
Phosphate, mg/dlg | 6.1±1.8 | 5.4±1.3 | 5.2±1.8 | −0.8±1.5 | 6.3±1.9 | −0.4±1.6 |
Carbon dioxide, mEq/Lg | 24.1±5.3 | 24.5±5.2 | 20.4±3.0 | −0.8±2.7 | 19.3±2.8 | 1.1±3.3 |
Values are means±SD. SBP, systolic BP; DBP, diastolic BP.
Taken on day 1.
Taken on day 29.
n=34.
n=36.
n=33.
n=31.
Taken before dialysis.