Table 3.
Comparison of maximum biomarker levels in infants with and without AKI
| Biomarker | Fold Difference for AKI versus No AKI | Median Values (IQR) in AKI Group (n=27) | Median Values (IQR) in Group Without AKI (n=84) | P Value |
|---|---|---|---|---|
| Albumin | 3.84×107 (2.72×107, 8.63×107) | 3.13×107 (2.09×107, 5.41×107) | 0.06 | |
| B2M | 13.4×106 (9.44×106, 19.3×106) | 12.1×106 (8.20×106, 15.6×106) | 0.37 | |
| Cystatin C | 2.0× higher | 18.9×105 (4.38×105, 34.2×105) | 9.13×105 (2.76×105, 18.4×105) | 0.01 |
| EGFa | 4.68×102 (3.63×102, 8.72×102) | 7.9×102 (4.96×102, 12.0×102) | 0.05 | |
| NGAL | 1.8× higher | 6.23×105 (3.43×105, 16.7×105) | 3.49×105 (2.04×105, 8.77×105) | 0.04 |
| OPN | 1.7× higher | 10.4×105 (5.05×105, 20.8×105) | 6.14×105 (4.11×105, 10.0×105) | 0.02 |
| UMODa | 1.6× lower | 5.20×105 (2.86×105, 7.28×105) | 8.33×105 (5.62×105, 11.8×105) | 0.001 |
| Clusterin | 1.7× higher | 4.25×105 (2.15×105, 5.20×105) | 2.45×105 (1.63×105, 3.90×105) | 0.05 |
| KIM-1 | 4.46×103 (2.21×103, 6.93×103) | 3.45×103 (1.97×103, 6.77×103) | 0.75 | |
| Osteoactivin | 1.99×103 (1.19×103, 2.45×103) | 2.09×103 (1.45×103, 2.82×103) | 0.31 | |
| TFF3 | 14.9×103 (6.22×103, 21.3×103) | 12.2×103 (7.10×103, 22.3×103) | 0.83 | |
| VEGF | 14.5×102 (11.1×102, 21.0×102) | 13.5×102 (9.8×102, 24.0×102) | 0.43 | |
| Calbindin | 8.67×103 (5.70×103, 20.1×103) | 8.73×103 (6.30×103, 15.9×103) | 0.79 | |
| α-GST | 3.7× higher | 91.0×101 (19.1×101, 400×101) | 24.0×101 (8.49×101, 95.1×101) | 0.004 |
Unless otherwise noted, values are maximum biomarker levels. Biomarker values are expressed as pg/ml. IQR, interquartile range; B2M, β2-microglobulin; EGF, epithelial growth factor; NGAL, neutrophil gelatinase-associated lipocalin; OPN, osteopontin; UMOD, uromodulin; KIM-1, kidney injury molecule 1; TFF3, trefoil factor 3; VEGF, vascular endothelial growth factor; α-GST, α-glutathione-S-transferase.
a
Minimum values.