Table 3.
Univariate regression analyses of composite outcome
| Variable | Unit Change | Univariate | ||
|---|---|---|---|---|
| Hazard Ratio | 95% CI | P Value | ||
| MBs | 4.62 | 3.22 to 6.62 | <0.001 | |
| Age | 1 yr | 1.03 | 1.02 to 1.05 | <0.001 |
| Sex | 0.86 | 0.59 to 1.23 | 0.42 | |
| BMI | 1 kg/m2 | 0.98 | 0.94 to 1.02 | 0.34 |
| Systolic BP | 10 mmHg | 1.31 | 1.23 to 1.40 | <0.001 |
| Diastolic BP | 10 mmHg | 1.17 | 1.00 to 1.36 | 0.05 |
| Pulse Pressure | 10 mmHg | 1.41 | 1.30 to 1.52 | <0.001 |
| eGFR | 1 ml/min per 1.73 m2 | 0.91 | 0.89 to 0.92 | <0.001 |
| Proteinuria | 1 g/Cre | 1.10 | 1.06 to 1.14 | <0.001 |
| Albumin | 1 g/dl | 0.71 | 0.57 to 0.90 | 0.004 |
| Total cholesterol | 1 mg/dl | 0.99 | 0.99 to 1.00 | <0.001 |
| Triglyceride | 1 mg/dl | 1.00 | 0.99 to 1.00 | 0.001 |
| HDL cholesterol | 1 mg/dl | 0.98 | 0.97 to 1.00 | <0.01 |
| Non-HDL cholesterol | 1 mg/dl | 0.80 | 0.70 to 0.90 | <0.001 |
| Hematocrit | 1% | 0.90 | 0.89 to 0.92 | <0.001 |
| Hemoglobin | 1 g/dl | 0.66 | 0.60 to 0.72 | <0.001 |
| Blood glucose | 1 mg/dl | 1.00 | 1.00 to 1.01 | 0.08 |
| HbA1c | 1% | 1.04 | 0.91 to 1.17 | 0.57 |
| Glycoalbumin | 1% | 1.05 | 1.01 to 1.08 | 0.01 |
| C-reactive protein | 1 mg/dl | 1.15 | 1.06 to 1.22 | 0.003 |
| Calcium | 1 mg/dl | 0.39 | 0.32 to 0.49 | <0.001 |
| Phosphate | 1 mg/dl | 2.00 | 1.75 to 2.27 | <0.001 |
| Intact PTH | 1 pg/ml | 1.00 | 1.00 to 1.00 | <0.001 |
| Smoking behavior | 1.14 | 0.79 to 1.65 | 0.45 | |
| Presence of diabetes | 1.77 | 1.24 to 2.54 | 0.002 | |
| Presence of hypertension | 3.31 | 2.14 to 5.33 | <0.001 | |
| Anticoagulation and/or antiplatelet therapy | 1.99 | 1.38 to 2.85 | <0.001 | |
95% CI, 95% confidence interval; MB, silent cerebral microbleed; BMI, body mass index; Cre, creatinine; HbA1c, hemoglobin A1c; PTH, parathyroid hormone.