Table 4.
Multivariate regression analyses
| Model | Adjustment | HR | 95% CI | P Value |
|---|---|---|---|---|
| Composite outcome | ||||
| 1 | Unadjusted | 4.62 | 3.22 to 6.62 | <0.001 |
| 2 | Age, sex, DM, and systolic BP | 2.58 | 1.68 to 3.96 | <0.001 |
| 3 | Model 2, eGFR, and UP | 2.61 | 1.69 to 4.04 | <0.001 |
| 4 | Model 2, BMI, Alb, and CRP | 3.18 | 2.04 to 4.97 | <0.001 |
| 5 | Model 2 and Hb | 2.58 | 1.70 to 3.92 | <0.001 |
| 6 | Model 2, Ca, P, and iPTH | 1.67 | 0.99 to 2.80 | 0.06 |
| 7 | Model 2, HDL cholesterol, non-HDL cholesterol, and smoking | 2.51 | 1.64 to 3.87 | <0.001 |
| Kidney outcome | ||||
| 1 | Unadjusted | 4.25 | 2.91 to 6.17 | <0.001 |
| 2 | Age, sex, DM, and systolic BP | 2.41 | 1.55 to 3.77 | <0.001 |
| 3 | Model 2, eGFR, and UP | 2.51 | 1.58 to 4.00 | <0.001 |
| 4 | Model 2, BMI, Alb, and CRP | 3.08 | 1.93 to 4.92 | <0.001 |
| 5 | Model 2 and Hb | 2.51 | 1.62 to 3.89 | <0.001 |
| 6 | Model 2, Ca, P, and iPTH | 1.52 | 0.88 to 2.61 | 0.13 |
| 7 | Model 2, HDL cholesterol, non-HDL cholesterol, and smoking | 2.36 | 1.50 to 3.69 | <0.001 |
| CVD outcome | ||||
| 1 | Unadjusted | 5.34 | 2.87 to 10.09 | <0.001 |
| 2 | Age, sex, DM, and systolic BP | 3.46 | 1.62 to 7.43 | 0.001 |
| 3 | Model 2, eGFR, and UP | 3.37 | 1.57 to 7.30 | 0.002 |
| 4 | Model 2, BMI, Alb, and CRP | 4.41 | 2.01 to 9.79 | <0.001 |
| 5 | Model 2 and Hb | 3.54 | 1.66 to 7.58 | 0.001 |
| 6 | Model 2, Ca, P, and iPTH | 1.96 | 0.74 to 5.25 | 0.18 |
| 7 | Model 2, HDL cholesterol, non-HDL cholesterol, and smoking | 3.33 | 1.53 to 7.25 | 0.003 |
HR, hazard ratio; 95% CI, 95% confidence interval; DM, diabetes mellitus; UP, proteinuria; BMI, body mass index; Alb, albumin; CRP, C-reactive protein; Hb, hemoglobin; Ca, calcium; P, phosphate; iPTH, intact parathyroid hormone; CVD, cardiovascular disease.