Table 1.
Altered Top 10 Highly Expressed Genes with Significant Fold Change (P < 0.05) in Pulmonary Arterial Hypertension Pericytes Versus Donor Control
| Up-regulated | Down-regulated | Gene symbol | Gene name | Normalized fold change | P value |
|---|---|---|---|---|---|
| + | PDK4 | Pyruvate dehydrogenase kinase 4 | 7.8 | 0.02929 | |
| + | G0S2 | G0/G1 switch gene 2 | 6.6 | 0.02626 | |
| + | ADH1A | Alcohol dehydrogenase 1A | 12.7 | 0.02771 | |
| + | RORB | RAR-related orphan receptor B | 4.7 | 0.00037 | |
| + | SPON1 | Spondin 1 | 4.6 | 0.01427 | |
| + | SIPA1L2 | Signal-induced proliferation-associated 1 like 2 | 4.6 | 0.00038 | |
| + | GPR64 | G protein–coupled receptor 64 | 13.1 | 0.00499 | |
| + | C4ORF31 | Fibronectin type III domain-containing protein | 5.8 | 0.02348 | |
| + | PF4V1 | Platelet factor 4 variant 1 | 7.4 | 0.04415 | |
| + | CHST15 | Carbohydrate sulfotransferase 15 | 11.3 | 0.00399 | |
| + | IGFBP2 | Insulin-like growth factor binding protein 2 | 5.6 | 0.0038 | |
| + | FBN2 | Fibrillin 2 | 8.8 | 0.00047 | |
| + | CYGB | Cytoglobin | 5.9 | 0.01236 | |
| + | ACTG2 | Actin, gamma 2 | 8.4 | 0.02231 | |
| + | MARCH4 | MARCH of membrane-bound E3 ubiquitin ligases | 4.8 | 0.01468 | |
| + | TMEM35 | Transmembrane protein 35 | 6.0 | 0.00413 | |
| + | NXN | Nucleoredoxin | 4.5 | 0.00288 | |
| + | RARRES3 | Retinoic acid receptor 3 | 4.3 | 0.02779 | |
| + | CPA4 | Carboxypeptidase A4 | 7.4 | 0.00969 | |
| + | HOXC8 | Homeobox C8 | 7.1 | 0.01314 |