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. 2014 Jun 15;46(7):693–700. doi: 10.1038/ng.3010

Figure 4. Expression and phylogenetic analysis of DNase II–like proteins from Trichuris species.

Figure 4

(a) Normalized transcript levels of the 18 genes encoding DNase II domain–containing proteins in T. muris, comparing the parasite anterior region with the posterior regions of adult female and male parasites. Indication of significant transcriptional upregulation in a particular pairwise comparison (Up) refers to FDR % 0.01 and FDR > 1 × 10−5 when denoted by one asterisk and to FDR % 1 × 10−5 when denoted by two asterisks. For a full version of this figure, see Supplementary Figure 4b. (b) A maximum-likelihood phylogeny of DNase II protein domains (IPR004947) shows the relationships between the DNase II domains of proteins from Trichuris species, T. spiralis, other nematodes, insects and other invertebrates, and vertebrates. See Supplementary Figure 6 for a fully annotated version of this tree. The circled numbers highlight individual sequences of particular interest: (1) TMUE_s0085001500 1–358 (T. muris), TTRE_0000372701 1–317 (T. trichiura) and E5SXW8_TRISP 8–361 (UniProt E5SXW8); (2) TMUE_s0015002900 1–191 and TTRE_0000937801 31–255; and (3) E5S4S7_TRISP 14–306 (UniProt E5S4S7).