Figure 3.

Retinal spreading depolarization (rSD) occurs following vessel occlusion. (a) Intrinsic optical signal (IOS) images of a representative rSD event in response to focal thrombosis of an arteriole (yellow dot). Numbers in the upper right of each panel indicate time relative to rSD initiation. (b) Images from the series shown in A, processed with each frame representing Δ intensity/intensity (ΔI/I) to better visualize the rSD wave front. Most rSD waves are initiated near the optic disc (red circle). (c) An rSD wave initiated following onset of global ischemia, produced by increasing intraocular pressure to ∼120 mmHg. The wave was initiated near the optic disc.