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. 2016 Jan 26;5(1):e282. doi: 10.1038/mtna.2015.56

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Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

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Nanoparticle characterization and knockdown efficiency. (a) Scanning electron micrograph shows the spherical morphology of the nanoparticles. (b) Western blot analysis showing in vitro knockdown efficiency of siRNA nanoparticles against mutant G12S K-ras in A549 cells. Nano K-ras represents antimutant K-ras siRNA-loaded hybrid nanoparticles, naked K-ras represents unencapsulated antimutant K-ras siRNA, Nano Scr represents scramble siRNA-loaded hybrid nanoparticles, and lipo K-ras represents antimutant K-ras siRNA transfected using lipofectamine 2000. (c) MTT assay showing in vitro antiproliferative activity of antimutant K-ras siRNA nanoparticles in A549 cells, n = 5, ***P ≤ 0.001.