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In vivo biodistribution studies. Biodistribution of antimutant K-ras siRNA following i.p. injection of siRNA in (a) functionalized hybrid nanoparticles and (b) naked siRNA. Lung data statistically compared to the next highest accumulation in tissues of the same time point. *P ≤ 0.05, **P ≤ 0.01, and ***P ≤ 0.001. n = 3.
