Fig 2. ASM overexpression protected females against the detrimental effects of amitriptyline on non-social memory performance.

Percentage investigation of the same and the novel object during the second 5 min of the novel object recognition test (A; n = 10–13 per group) and during the discrimination period of the object discrimination test (B; n = 6 per group). Mice were treated with amitriptyline (black bars) or water (grey bars) for 4 weeks before and during behavioral testing. Object recognition (A) and object memory (B), as indicators of intact non-social memory, are reflected by higher investigation time directed towards the novel versus the same object. Shown are means + SEM. * p<0.05 versus same object.