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. 2016 Sep 6;12(9):e1006295. doi: 10.1371/journal.pgen.1006295

Fig 9. Df. causes genome-wide gene expression change in a genetic background-dependent manner.

Fig 9

A, B) Adjusted p values of gene expression change is plotted in–log scale across the genome for females (A) and males (B) of Df(2L)ED136/+ flies. The grey region on chromosome 2L indicates the deletion. The threshold adjusted p = 0.05 is shown (dotted lines). CG18600 displayed significant changes in both genetic backgrounds and sexes. C, D) Gene expression changes of Df/+ genes (diamond) and their two dose 1° neighbors (circle) genes in the integrated gene network of female Df(2L)ED778/+ flies from isogenic (C) and hybrid (D) genetic backgrounds. E, F) Overlap of gene expression changes between Df/+ genes, and their two dose 1°, 2°, and 3° neighbors between two different genetic backgrounds in females (E) and males (F). We called genes whose changes are greater than 1.5 folds and show same directional changes (up or down) in both genetic backgrounds to be overlapped. For brevity, “Df(2L)” and “/+” are omitted in genotypes. E.g. Df(2L)ED105/+ is shown as ED105.