Table 1.
Baseline demographics and patient characteristics of less symptomatic and more symptomatic patients according to baseline E-RS and BDI
| Demographic parameter | E-RS
|
BDI
|
||
|---|---|---|---|---|
| Less symptomatic (E-RS <10) n=1,172 |
More symptomatic (E-RS ≥10) n=2,164 |
Less symptomatic (BDI ≥7) n=1,519 |
More symptomatic (BDI <7) n=1,778 |
|
| Age, mean (SD) | 64.2 (8.3) | 63.1 (8.5) | 63.5 (8.3) | 63.5 (8.6) |
| Sex, male, % | 59.1 | 61.2 | 61.2 | 60.1 |
| COPD severity (GOLD stages) (%) | ||||
| Stage II (moderate) | 68.5 | 53.1 | 66.8 | 51.4 |
| Stage III (severe) | 31.1 | 46.2 | 32.5 | 48.1 |
| Current smoker, % | 44.4 | 52.0 | 49.5 | 49.3 |
| Smoking history, pack-years, mean (SD) | 47.2 (24.4) | 45.8 (24.2) | 45.5 (23.7) | 47.0 (24.8) |
| No exacerbations in previous | 0.3 (0.6) | 0.5 (0.9) | 0.3 (0.7) | 0.5 (0.9) |
| 12 months, mean (SD) | ||||
| Baseline FEV1, L, mean (SD) | 1.4 (0.5) | 1.4 (0.5) | 1.5 (0.5) | 1.3 (0.5) |
| Baseline FVC, L, mean (SD) | 2.9 (0.9) | 2.8 (0.9) | 3.0 (0.9) | 2.8 (0.8) |
| FEV1/FVC, %, mean (SD) | 48.8 (10.4) | 47.3 (10.9) | 49.2 (10.5) | 46.3 (10.9) |
| E-RS total score at baseline (SD) | 5.7 (2.8) | 16.3 (4.6) | 10.3 (5.9) | 14.5 (6.4) |
| BDI score at baseline (SD) | 7.5 (2.1) | 5.9 (2.0) | 8.2 (1.4) | 4.9 (1.4) |
Abbreviations: BDI, Baseline Dyspnea Index; COPD, chronic obstructive pulmonary disease; E-RS, Evaluating Respiratory Symptoms; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; GOLD, Global initiative for chronic Obstructive Lung Disease; SD, standard deviation.