Table 3.
Recommended Initial Antiretroviral Therapy Regimensa
| Regimen | Rating |
|---|---|
| Dolutegravir/abacavir/lamivudine | AIa |
| Dolutegravir plus tenofovir alafenamide/emtricitabineb | AIa |
| Elvitegravir/cobicistat/tenofovir alafenamide/emtricitabineb | AIa |
| Raltegravir plus tenofovir alafenamide/emtricitabineb | AIII |
a
Regimens are listed in alphabetic order by integrase strand transfer inhibitor component. Components separated with a slash (/) indicate that they are available as coformulations.
b
In settings in which tenofovir alafenamide/emtricitabine is not available, tenofovir disoproxil fumarate (with emtricitabine or lamivudine) remains an effective and generally well-tolerated option. Given the limited long-term experience with tenofovir alafenamide, some clinicians may prefer to continue using tenofovir disoproxil fumarate pending broader experience with tenofovir alafenamide in clinical practice.