Table 2. Dose Levels in Phase I Portion of the Study.
Dose Level | Ifosfamide Dose | Paclitaxel Dose | Carboplatin Dose | |||
---|---|---|---|---|---|---|
Daily Dose | Total Dose per Cycle | Daily Dose | Total Dose per Cycle | Daily Dose | Total Dose per Cycle | |
1 | 2 g/m2 × 3 days | 6g/m2 | 200 mg/m2 × 1 day | 200 mg/m2 | AUC=7 | AUC=21 |
2 | 2.67 g/m2 × 3 days | 8g/m2 | 200 mg/m2 × 1 day | 200 mg/m2 | AUC=7 | AUC=21 |
3 | 3.33 g/m2 × 3 days | 10g/m2 | 200 mg/m2 × 1 day | 200 mg/m2 | AUC=7 | AUC=21 |
4 | 3.33 g/m2 × 3 days | 10g/m2 | 250 mg/m2 × 1 day | 250 mg/m2 | AUC=7 | AUC=21 |
5 | 3.33 g/m2 × 3 days | 10g/m2 | 250 mg/m2 × 1 day | 250 mg/m2 | AUC=8 | AUC=24 |
Abbreviations: AUC, area under the curve