Table 4. Kaplan-Meier Overall Survival Estimates by Histology, Stage, and Modified IGCCCG Risk Group.

Initial Treatment Characteristics	1-year OS (95% CI)	3-year OS (95% CI)	Log-rank p-value#
Full cohort (n=93)	0.94 (0.90-0.99)	0.84 (0.76-0.92)	-
Histology (n=90)*			0.44
Dysgerminoma (24)	0.96 (0.88-1.00)	0.96 (0.88-1.00)
Endodermal sinus tumor (18)	0.94 (0.84-1.00)	0.83 (0.66-1.00)
Immature teratoma (28)	0.92 (0.83-1.00)	0.84 (0.71-1.00)
Mixed GCT (20)	1.00 (1.00-1.00)	0.80 (0.62-1.00)
			0.12
Dysgerminoma (24)	0.96 (0.88-1.00)	0.96 (0.88-1.00)
Other (66)	0.95 (0.90-1.00)	0.83 (0.73-0.93)
Stage (n=93)			0.049
I/II (57)	0.96 (0.91-1.00)	0.90 (0.81-0.99)
III/IV (34)	0.91 (0.82-1.00)	0.77 (0.63-0.94)
Late stage (n=36)			0.018
III (29)	0.97 (0.90-1.00)	0.80 (0.65-0.98)
IV (7)	0.71 (0.45-1.00)	0.57 (0.30-1.00)
Modified pre-chemotherapy ICGGGC Group (n=84)**			<0.001***
Good (48)	0.98 (0.94-1.00)	0.90 (0.80-1.00)
Intermediate (12)	1.00	0.89 (0.71-1.00)
Poor (11)	0.70 (0.47-1.00)	0.47 (0.23-0.94)
Unable to classify (13)	0.91 (0.75-1.00)	0.73 (0.51-1.00)
Modified preoperative ICGGGC Group (n=83)**			<0.001****
Good (26)	0.96 (0.89-1.00)	0.91 (0.79-1.00)
Intermediate (9)	1.00	0.80 (0.52-1.00)
Poor (13)	0.77 (0.57-1.00)	0.50 (0.28-0.89)
Unable to classify (35)	0.97 (0.91-1.00)	0.87 (0.76-1.00)

Abbreviations: GCT, germ cell tumor; IGCCCG, International Germ Cell Cancer Collaborative Group

^*Excluding teratoma with malignant transformation and choriocarcinoma due to small sample sizes.

^**One patient excluded from PFS/OS analyses for both preoperative and pre-chemotherapy models due to lack of a chemotherapy start date. One additional patient excluded from preoperative model because she did not undergo primary surgery.

^***Includes unclassifiable patients. With exclusion of unclassifiable patients, remains P <0.001.

^****Includes unclassifiable patients. With exclusion of unclassifiable patients, P=0.001.

^#Note that the log-rank test compares Kaplan Meier survival function over time.