Table 3.

Multivariable Adjusted HRs for Overall Survival (Reference: Cystectomy With or Without Adjuvant Chemotherapy)

Analysis	Treatment	Univariable HR (95% CI)	Multivariable HR (95% CI)*
Overall, uncensored	Chemotherapy alone	1.29 (1.14 to 1.47)	1.33 (1.17 to 1.53)
	Preoperative chemotherapy	0.78 (0.67 to 0.92)	0.94 (0.79 to 1.12)
Overall, censored for adjuvant chemotherapy	Chemotherapy alone	1.10 (0.95 to 1.26)	1.14 (0.97 to 1.33)
	Preoperative chemotherapy	0.66 (0.55 to 0.79)	0.80 (0.66 to 0.97)
Overall, censored for adjuvant chemotherapy, adjusted for pathologic stage and surgical margin status	Preoperative chemotherapy	0.84 (0.69 to 1.03)	0.99 (0.80 to 1.22)
Cystectomy only, adjusted for pathologic stage and surgical margin status	Adjuvant chemotherapy	0.65 (0.54 to 0.78)	0.68 (0.56 to 0.83)

Abbreviation: HR, hazard ratio.

^*Multivariable models included age, gender, race, insurance status, median income, education, Charlson Comorbidity Index, year of diagnosis, facility type, facility location, facility setting, distance to facility, annual cystectomy volume, clinical T stage, and clinical N stage.