(A) Progression-free (PFS) and (B) overall survival (OS) of patients receiving CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) for eight cycles (CHOP8) or CHOP for three cycles plus radiotherapy (CHOP3RT) with prolonged follow-up. 5-, 10-, and 15-year estimates are included. (*) Two-sided log-rank test.