Table 3.
Second Malignancies Developed by Patients in S8736
| Second Malignancy Type | CHOP8 (n = 24) | CHOP3RT (n = 30) | Total (n = 54) |
|---|---|---|---|
| Nonmelanoma skin | 11 | 6 | 17 |
| Genitourinary | 4 | 5 | 9 |
| Prostate | 2 | 4 | 6 |
| Bladder | 2 | 0 | 2 |
| Cervical | 0 | 1 | 1 |
| Lung | 2 | 6 | 8 |
| Breast | 4 | 3 | 7 |
| GI | 1 | 4 | 5 |
| Colon | 0 | 2 | 2 |
| Rectum | 1 | 0 | 1 |
| Pancreas | 0 | 2 | 2 |
| Hematologic | 2 | 3 | 5 |
| Chronic myelomonocytic leukemia | 1 | 0 | 1 |
| Low-grade non-Hodgkin lymphoma | 0 | 2 | 2 |
| Multiple myeloma | 1 | 0 | 1 |
| Myelofibrosis | 0 | 1 | 1 |
| Melanoma | 0 | 3 | 3 |
Abbreviations: CHOP3RT, three cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) plus radiotherapy; CHOP8, eight cycles of CHOP.