Table 3.

Primary Analysis: Multivariable Model of ColDx Signature Score and Potentially Prognostic Covariates of RFI

Factor	HR (95% CI)	P
ColDx signature score (high risk v low risk)	2.13 (1.3 to 3.5)	< .01
Age (continuous)	1.02 (1.00 to 1.04)	.07
Sex (male v female)	0.94 (0.59 to 1.47)	.78
T stage (T4 v T3)	0.78 (0.20 to 3.0)	.72
Nodes examined (continuous)	0.98 (0.95 to 1.01)	.11
Tumor grade (high v low)	1.47 (0.82 to 2.6)	.19
Tumor location (proximal v distal)	1.24 (0.74 to 2.1)	.41
MMR (deficient v intact)	0.55 (0.29 to 1.02)	.05

NOTE. n = 377 with 91 RFI events.

Abbreviations: HR, hazard ratio; MMR, mismatch repair; RFI, recurrence-free interval.