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. Author manuscript; available in PMC: 2017 Mar 18.
Published in final edited form as: Circ Res. 2016 Jan 7;118(6):994–1007. doi: 10.1161/CIRCRESAHA.115.305376

Figure 4. GRP30 activation via endothelium-independent or endothelium-dependent mechanisms.

Figure 4

A: Endothelium-independent effect is mediated by a large conductance calcium-activated potassium channel leading to an increase in potassium efflux. This effect results in coronary artery relaxation. BK, Ca2+- and voltage-activated K+ channels. B: Endothelium-dependent mechanism. Estrogen binding to GPR30 leads to activation of eNOS raising the production of nitric oxide (NO) in coronary endothelial cells to relax these arteries.