Table 1.

Studies of reslizumab in asthma

Study	Study design	Number of patients	Population	Regimen	Main findings
Kips et al21	Randomized, double blind	32	Symptomatic severe persistent asthmatics despite using high-dose inhaled or oral corticosteroids	Single dose of reslizumab IV at doses ranging from 0.03 to 1.0 mg/kg or placebo	No biological activity seen at doses below 0.03 mg/kg. Dose of 1.0 mg/kg produced a significant reduction in eosinophil counts. No improvement in pulmonary function or symptom scores
Castro et al22	Multicenter, randomized, double blind, placebo controlled	106	Poorly controlled asthmatics with airway reactivity, on high-dose ICS+ to a second controller, and sputum eosinophils ≥3%	Reslizumab 3.0 mg/kg IV or placebo at baseline and at weeks 4, 8, and 12	A trend toward improved ACQ scores, with patients with nasal polyps with a more substantial response. A trend toward improvement in exacerbation rates (8% vs 19%). Eosinophils significantly decreased in sputum
Castro et al26	Two replicate trials, multicenter, randomized, double blind, placebo controlled	953	Poorly controlled asthmatics despite using at least medium-dose ICS with or without a controller and a blood eosinophil count of ≥400 cells per µL	Reslizumab 3 mg/kg IV or placebo every 4 weeks × 13 doses	Reduction in rates of asthma exacerbations and improvement in FEV1 and asthma control
Corren et al27	Multicenter, randomized, double blind, placebo controlled	496	Poorly controlled asthmatics despite using at least medium-dose ICS with or without a controller without preselection eosinophil count criteria	Reslizumab 3.0 mg/kg IV or placebo every 4 weeks × 4 doses	No difference in FEV1 in both study groups. Subgroup analysis in subjects with blood eosinophil count of ≥400 cells per µL had improvements in FEV1, ACQ scores, and rescue inhaler use
Bjermer et al28	Multicenter, randomized, double blind, placebo controlled	315	Poorly controlled asthmatics despite using at least medium-dose ICS with or without a controller and a blood eosinophil count of ≥400 cells per µL	Reslizumab 0.3 or 3.0 mg/kg IV or placebo every 4 weeks × 4 doses	The 3.0 mg/kg dose had improvement in pulmonary function and self-reported asthma control and quality of life

Abbreviations: ACQ, asthma control questionnaire; FEV₁, forced expiratory volume in 1 second; ICS, inhaled corticosteroids; IV, intravenous.