Table 1.
Pharmacokinetic profile of cannabinoids and metabolites (cannabinoid and metabolite concentrations are reported in ng/ml)
| Parameter | Dose (%) | Time (minutes) | Delta-9-THC | 11-OH-THC | THC-COOH | CBD | CBN |
|---|---|---|---|---|---|---|---|
| N | 2.9 | 240 | 37 | 37 | 37 | 37 | 37 |
| Average | 25.0 | 1.7 | 18.8 | 0 | 0.6 | ||
| SD | 19.1 | 1.9 | 33.0 | 0 | 1.2 | ||
| Minimum | 2.1 | 0 | 0 | 0 | 0 | ||
| Median | 23.3 | 1.9 | 2.4 | 0 | 0 | ||
| Maximum | 68.5 | 5.6 | 122.7 | 0 | 3.8 | ||
| %CV | 77 | 113 | 175 | NA | 199 | ||
| N | 6.7 | 240 | 37 | 38 | 38 | 38 | 38 |
| Average | 50.0 | 3.2 | 21.2 | 0.9 | 0.5 | ||
| SD | 39.7 | 3.5 | 32.0 | 1.6 | 1.3 | ||
| Minimum | 0 | 0 | 0 | 0 | 0 | ||
| Median | 46.8 | 2.51 | 7.59 | 0 | 0 | ||
| Maximum | 177.3 | 12.8 | 146.2 | 6.4 | 5.5 | ||
| %CV | 79 | 111 | 151 | 169 | 253 | ||
| N | 2.9 | 420 | 37 | 37 | 37 | 37 | 37 |
| Average | 0.9 | 0.2 | 17.5 | 0 | 0 | ||
| SD | 2.3 | 0.7 | 32.7 | 0 | 0 | ||
| Minimum | 0 | 0 | 0 | 0 | 0 | ||
| Median | 0 | 0 | 2.08 | 0 | 0 | ||
| Maximum | 9.98 | 3.54 | 115.72 | 0 | 0 | ||
| %CV | 260 | 354 | 187 | NA | NA | ||
| N | 6.7 | 420 | 39 | 39 | 39 | 39 | 39 |
| Average | 1.2 | 0.4 | 19.6 | 0 | 0 | ||
| SD | 2.8 | 1.2 | 32.6 | 0 | 0 | ||
| Minimum | 0 | 0 | 0 | 0 | 0 | ||
| Median | 0 | 0 | 6.16 | 0 | 0 | ||
| Maximum | 13.92 | 6.46 | 147.88 | 0 | 0 | ||
| %CV | 235 | 326 | 166 | NA | NA |
Notes: 2.9, 2.9% delta-9-THC; 6.7, 6.7% delta-9-THC; 240, 240 minutes (second vaporization administration); 420, 420 minutes (recovery period).
Abbreviations: CBD, cannabidiol; CBN, cannabinol; SD, standard deviation; %CV, percent coefficient of variation; THC, tetrahydrocannabinol; 11-OH-THC, 11-hydroxy-THC; THC-COOH, 11-nor-9-carboxy-THC.