Table 2.
P-values and effects for linear mixed model estimation of plasma levels of delta-9-THC and metabolites
| Effect | Delta-9-THC | 11-OH-THC | THC-COOH | CBD | CBN |
|---|---|---|---|---|---|
| Dose | <0.0001 | 0.0005 | 0.1973 | <0.0001 | 0.5657 |
| Time | <0.0001 | 0.0008 | 0.4756 | >0.99 | 0.0019 |
| Dose × time | 0.0003 | 0.0243 | 0.9215 | 0.0005 | 0.7237 |
| Direction of effectsa | 6.7 at 240> | 6.7 at 240> | 6.7 at 240> | ||
| 2.9 at 240> | 2.9 at 240> | 2.9 at 240= | |||
| 2.9 at 420= | 2.9 at 420= | 2.9 at 420= | |||
| 6.7 at 420 | 6.7 at 420 | 6.7 at 420 |
Notes:
a
When statistically significant interactions were identified, the direction of effects is provided and presented vertically to provide comparisons of plasma concentrations.
Abbreviations: 2.9, 2.9% delta-9-THC; 6.7, 6.7% delta-9-THC; 240, 240 minutes (second vaporization administration); 420 minutes (recovery period); CBD, cannabidiol; CBN, cannabinol; THC, tetrahydrocannabinol; 11-OH-THC, 11-hydroxy-THC; THC-COOH, 11-nor-9-carboxy-THC.