Table 4.
Linear mixed model estimation of the percent change from baseline of NPS items by cannabinoid blood levels, adjusted for baseline scores
| NPS–cannabinoid | β | Standard error | 95% confidence interval end points
|
|||
|---|---|---|---|---|---|---|
| Lower | Upper | P (unadjusted) | P (FDR) | |||
| Intensity–THC | −0.001 | 0.002 | −0.004 | 0.003 | 0.6807 | 0.9662 |
| Intensity–11-OH-THC | 0.007 | 0.020 | −0.032 | 0.046 | 0.7186 | 0.9662 |
| Intensity–THC-COOH | 0.000 | 0.002 | −0.004 | 0.004 | 0.9737 | 0.9887 |
| Intensity–CBD | −0.050 | 0.046 | −0.142 | 0.042 | 0.2858 | 0.9662 |
| Intensity–CBN | 0.003 | 0.047 | −0.090 | 0.097 | 0.9408 | 0.9887 |
| Sharpness–THC | −0.001 | 0.002 | −0.005 | 0.002 | 0.4683 | 0.9662 |
| Sharpness–11-OH-THC | 0.005 | 0.022 | −0.037 | 0.048 | 0.8041 | 0.9662 |
| Sharpness–THC-COOH | −0.003 | 0.002 | −0.007 | 0.001 | 0.1031 | 0.8592 |
| Sharpness–CBD | −0.046 | 0.050 | −0.145 | 0.052 | 0.3524 | 0.9662 |
| Sharpness–CBN | 0.009 | 0.050 | −0.092 | 0.109 | 0.8666 | 0.9662 |
| Burning–THC | −0.004 | 0.002 | −0.007 | −0.001 | 0.0105 | 0.2875 |
| Burning–11-OH-THC | −0.030 | 0.017 | −0.064 | 0.004 | 0.0823 | 0.8592 |
| Burning–THC-COOH | −0.003 | 0.002 | −0.008 | 0.002 | 0.1982 | 0.9662 |
| Burning–CBD | −0.045 | 0.039 | −0.123 | 0.032 | 0.2509 | 0.9662 |
| Burning–CBN | 0.011 | 0.042 | −0.071 | 0.094 | 0.7870 | 0.9662 |
| Aching–THC | −0.001 | 0.002 | −0.006 | 0.003 | 0.5455 | 0.9662 |
| Aching–11-OH-THC | −0.004 | 0.024 | −0.051 | 0.043 | 0.8696 | 0.9662 |
| Aching–THC-COOH | −0.002 | 0.003 | −0.008 | 0.005 | 0.6063 | 0.9662 |
| Aching–CBD | −0.040 | 0.053 | −0.144 | 0.065 | 0.4552 | 0.9662 |
| Aching–CBN | −0.010 | 0.057 | −0.124 | 0.103 | 0.8546 | 0.9662 |
| Cold–THC | −0.002 | 0.004 | −0.01 | 0.006 | 0.6517 | 0.9662 |
| Cold–11-OH-THC | 0.000 | 0.034 | −0.068 | 0.069 | 0.9887 | 0.9887 |
| Cold–THC-COOH | −0.003 | 0.005 | −0.013 | 0.007 | 0.5579 | 0.9662 |
| Cold–CBD | 0.006 | 0.082 | −0.158 | 0.170 | 0.9397 | 0.9887 |
| Cold–CBN | −0.018 | 0.079 | −0.176 | 0.140 | 0.8199 | 0.9662 |
| Sensitive–THC | 0.001 | 0.002 | −0.002 | 0.004 | 0.5074 | 0.9662 |
| Sensitive–11-OH-THC | 0.009 | 0.018 | −0.027 | 0.045 | 0.6297 | 0.9662 |
| Sensitive–THC-COOH | −0.003 | 0.003 | −0.008 | 0.003 | 0.3237 | 0.9662 |
| Sensitive–CBD | −0.010 | 0.041 | −0.090 | 0.071 | 0.8120 | 0.9662 |
| Sensitive–CBN | 0.058 | 0.045 | −0.032 | 0.148 | 0.2012 | 0.9662 |
| Itching–THC | −0.002 | 0.002 | −0.005 | 0.002 | 0.3407 | 0.9662 |
| Itching–11-OH-THC | −0.022 | 0.013 | −0.048 | 0.005 | 0.1025 | 0.8592 |
| Itching–THC-COOH | −0.003 | 0.003 | −0.009 | 0.003 | 0.0364* | 0.6067 |
| Itching–CBD | −0.030 | 0.031 | −0.093 | 0.033 | 0.3481 | 0.9662 |
| Itching–CBN | −0.031 | 0.033 | −0.098 | 0.036 | 0.3520 | 0.9662 |
| Unpleasant–THC | 0.000 | 0.002 | −0.004 | 0.004 | 0.9658 | 0.9887 |
| Unpleasant–11-OH-THC | −0.007 | 0.023 | −0.052 | 0.038 | 0.7631 | 0.9662 |
| Unpleasant–THC-COOH | −0.004 | 0.003 | −0.011 | 0.003 | 0.2155 | 0.9662 |
| Unpleasant–CBD | −0.015 | 0.050 | −0.115 | 0.085 | 0.7664 | 0.9662 |
| Unpleasant–CBN | −0.024 | 0.055 | −0.133 | 0.085 | 0.6687 | 0.9662 |
| Deep pain–THC | −0.001 | 0.002 | −0.005 | 0.002 | 0.4321 | 0.9662 |
| Deep pain–11-OH-THC | −0.026 | 0.018 | −0.062 | 0.010 | 0.1535 | 0.9662 |
| Deep pain–THC-COOH | −0.005 | 0.002 | −0.008 | −0.001 | 0.0115 | 0.2875 |
| Deep pain–CBD | −0.019 | 0.042 | −0.101 | 0.064 | 0.6571 | 0.9662 |
| Deep pain–CBN | −0.009 | 0.044 | −0.097 | 0.078 | 0.8321 | 0.9662 |
| Superficial–THC | −0.001 | 0.002 | −0.004 | 0.002 | 0.6241 | 0.9662 |
| Superficial–11-OH-THC | −0.012 | 0.019 | −0.050 | 0.026 | 0.5292 | 0.9662 |
| Superficial–THC-COOH | 0.003 | 0.002 | −0.002 | 0.007 | 0.2134 | 0.9662 |
| Superficial–CBD | −0.034 | 0.043 | −0.120 | 0.052 | 0.4327 | 0.9662 |
| Superficial–CBN | 0.020 | 0.046 | −0.071 | 0.111 | 0.6715 | 0.9662 |
Notes: Significant unadjusted P-values are in bold.
*
P-value for interaction term. β, regression coefficient; P (FDR), false-discovery-rate-adjusted P-value.
Abbreviations: CBD, cannabidiol; CBN, cannabinol; 11-OH-THC, 11-hydroxy-THC; NPS, Neuropathic Pain Scale; THC, tetrahydrocannabinol; THC-COOH, 11-nor-9-carboxy-THC.