Fig. 5.

Pathway selectivity of CMF-019 determined from cell-based assays. The concentration response curves for [Pyr¹]apelin-13 (●) and CMF-019 (■) in cell-based cAMP (A, ●n = 8/4, ■n = 11/4), β-arrestin (B, ●n = 12/4, ■n = 13/4) and internalisation (C, ●n = 6/2, ■n = 6/2) assays. Bias was calculated as described previously [35], relative effectiveness (RE) and bias factors (BF) are shown in Table 1, Table 2 respectively.