Table II.
Antiviral RNAi Clinical Trials with Virus Name, Target Gene(s), Mode of RNAi Induction, Delivery, Stage of Trial, Sponsors and Year the Trial was Started
| Virus | Target | Delivery and mode of induction | Stage | Sponsors | Year started | Reference |
|---|---|---|---|---|---|---|
| RSV | Nucleocapsid | siRNA nasal spray | Phase II | Alnylam | 2008 | (143) |
| HBV | Four different HBV targets | Intravenous injection of liposome-encapsulated shRNA expression plasmid | Phase I | Nucleonics | 2007 | (144) |
| HCV | miR-122 | Subcutaneous injections of LNA | Phase II | Santaris | 2010 | (219) |
| HIV | tat/rev | Ex vivo transduction by retroviral vector | Phase I | City of Hope, Benitec | 2007 | (66) |