Table 1.
Clinical characteristics of all patients
| Overall (n=88) | Treatment responder (n=77) | Treatment failure (n=11) | p-value* | Treatment success with no recurrence (n=55) | Treatment success with recurrence (n=22) | p-value** | |
|---|---|---|---|---|---|---|---|
| Age (median) | 52.7 | 53.8 | 49.9 | 0.67 | 55.6 | 49.0 | 0.62 |
| Sex (% female) | 60.2 | 59.7 | 63.6 | 0.8 | 58.2 | 63.6 | 0.65 |
| BMI, mean (Kg/M2) | 27.5 | 27.4 | 28.1 | 0.75 | 27.7 | 26.6 | 0.44 |
| Charlson comorbidity index | 1.32 | 1.32 | 1.27 | 0.53 | 1.34 | 1.27 | 0.49 |
| Prior antibiotic exposure (%) | 59.1 | 55.8 | 81.8 | 0.1 | 56.4 | 54.5 | 0.88 |
| Community-acquired (%) | 59.1 | 62.3 | 36.4 | 0.13 | 63.6 | 59.1 | 0.9 |
| Severe CDI (%) | 7 | 5.2 | 18.2 | 0.1 | 5.5 | 4.5 | 0.86 |
| Concomitant antibiotic exposure (%) | 28.4 | 27.2 | 36.4 | 0.5 | 27.3 | 27.3 | 1.0 |
| Concomitant PPI exposure (%) | 27.3 | 25.9 | 36.3 | 0.48 | 18.2 | 45.5 | 0.01 |
| Treatment with metronidazole (%) | 70.5 | 70.1 | 72.7 | 0.8 | 72.7 | 63.6 | 0.1 |
| Treatment with vancomycin (%) | 23.9 | 24.7 | 18.2 | 0.8 | 20.0 | 36.4 | 0.1 |
| Treatment with vancomycin and metronidazole | 5.6 | 5.2 | 9.1 | 0.8 | 7.3 | 0 | 0.1 |
*
Denotes p-value for comparison of treatment responders versus treatment failures
**
Denotes p-value for comparison of recurrent infections versus non-recurrent infection
CDI = Clostridium difficile infection, BMI = Body mass index, PPI = Proton pump inhibitor