Table 2. Clinical characteristics of patientsφ.
| Characteristic | Only EPTB n=46 (%) | Some form of PTB n=117(%) | p-value |
|---|---|---|---|
| Initial Symptoms* | |||
| Cough | 14 (30.4) | 72 (61.5) | <0.001 |
| Lymphadenopathy | 14 (30.4) | 8 (6.8) | <0.001 |
| Weight loss | 13 (28.3) | 56 (47.9) | 0.023 |
| Fever | 13 (28.3) | 43 (36.8) | 0.304 |
| Chest pain | 7 (15.2) | 24 (20.5) | 0.438 |
| Anorexia | 6 (13.0) | 22 (18.8) | 0.380 |
| Night sweats | 5 (10.9) | 46 (39.3) | <0.001 |
| Altered mental status | 5 (10.9) | 5 (4.3) | 0.114 |
| Back pain | 3 (6.5) | 1 (0.9) | 0.035 |
| Shortness of breath | 3 (6.5) | 5 (4.3) | 0.550 |
| Malaise | 2 (4.3) | 9 (7.7) | 0.444 |
| Hemoptysis | 1 (2.2) | 9 (7.7) | 0.186 |
| GI symptoms | 5 (10.9) | 7 (6.0) | 0.282 |
| EPTB disease site† | |||
| Lymph Node | 14 (30.4) | ||
| Pleural | 11 (23.9) | ||
| Bone | 9 (19.6) | ||
| CNS TB | 7 (15.2) | ||
| GI | 4 (8.7) | ||
| Other | 1 (2.2) | ||
| Diagnosis** | |||
| Microbiologic | 32 (69.6) | 94 (80.3) | 0.126 |
| Pathologic | 4 (8.7) | 1 (0.9) | 0.022 |
| Clinical | 10 (21.7) | 22 (18.8) | 0.672 |
PTB = pulmonary tuberculosis; EPTB = extrapulmonary tuberculosis; CNS=central nervous system; GI=gastrointestinal
Pearson's χ squared tests used for all analyses
Analysis of clinical symptoms of some form of EPTB vs. only PTB: some form of EPTB vs. only PTB less likely to have cough (25/64 [39.1%] vs. 61/99 [61.6%]; p=0.005) and hemoptysis (1/64 [1.6%] vs. 9/99 [9%]; p=0.05). Some form of EPTB more likely to have lymphadenopathy than only PTB (18/64 [28.1%] vs. 4/99 [4%]; p<0.001) and GI symptoms (10/64 [15.6%] vs. 2/99 [2%]; p=0.001). No other differences found.
EPTB disease sites for EPTB/PTB were as follows (n): lymph node (6), pleural (6), bone (1), CNS TB (1), GI (1), miliary (3)
More persons with EPTB/PTB had microbiological diagnosis than only PTB or EPTB (17/18 [94.4%] for EPTB/PTB; 77/99 [77.8%] for only PTB; 32/46 [69.6%] for only EPTB), but was not significant (p=0.158). More persons with only EPTB had pathologic diagnosis than only PTB or PTB/EPTB (4/46 [8.7%] for EPTB only; 1/99 for PTB only [1.0%]; 0/18 [0.0%] for EPTB/PTB); was not significant (p=.053). No difference in clinical diagnosis among only PTB, only EPTB, and EPTB/PTB (21/99 [21.2%]; 10/46 [21.7%]; 1/18 [5.6%], respectively; p=.028).