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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Cell Calcium. 2016 Mar 14;60(3):155–162. doi: 10.1016/j.ceca.2016.03.007

Figure 1.

Figure 1

Cinnamaldehyde, the TRPA1 agonist, activates airway C fibers and causes cough. A, Dose-response curve of cinnamaldehyde and allyl isothiocyanate on mouse TRPA1-expressing CHO cells using FLIPR. Each datapoint represents an average of four to eight independent readings. Taken from [76]. B, Representative action potential discharge in mouse bronchopulmonary C fiber (recorded ex vivo) in response to cinnamaldehyde (CA) during perfusion with vehicle and after 15 min pretreatment with the TRP channel blocker ruthenium red (30 μM). Taken from [33]. C and D, Mean ± SEM coughs evoked by aerosolized cinnamaldehyde-induced cough in guinea pigs. C, Dose-response relationship. D, Effect of aerosolized TRPA1 inhibitor HC-030031 (HC, 0.3 mM) or TRPV1 inhibitor capsazepine (CPZ, 10 μM) on cough induced by cinnamaldehyde (10 mM) in guinea pig. *P < 0.05, significant difference versus vehicle (VEH, 5% ethanol and 3.5% Tween-80 in isotonic saline). # P < 0.05, significant difference to cinnamaldehyde without inhibitor. Taken from [103].