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. Author manuscript; available in PMC: 2017 Sep 6.
Published in final edited form as: ChemMedChem. 2016 Jul 26;11(17):1915–1923. doi: 10.1002/cmdc.201600311

Figure 3.

Figure 3

X-ray structures of heptaprenyl and hexaprenyl diphosphate synthases. a) Structure of the dimeric protein SaHepPPS (PDB:5H9D) where HepPPS-1 is shown in teal. and HepPPS-2 is shown in yellow. The FARM and SARM Asp-rich motifs in the active site are shown as red spheres and are in the HepPPS-2 catalytic protein. b) Superimposition of SaHepPPS (cyan) and MlHexPPS (green; PDB:3AQB) structures. c) View of the highly conserved residues (in pink) that are located at or near the interface between SaHepPPS-1 (teal) and SaHepPPS-2 (yellow); FARM/SARM motifs are shown in red. The conserved residues at or near the interface were deduced from the ClustalW alignments shown in Figure 4.