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. Author manuscript; available in PMC: 2017 Sep 6.
Published in final edited form as: ChemMedChem. 2016 Jul 26;11(17):1915–1923. doi: 10.1002/cmdc.201600311

Figure 6.

Figure 6

Dose-response curves and chain-length dependence of log(IC50) for HepPPS by bisphosphonates. a) Dose-response curves for SaHepPPS inhibition by 1-H analogs of zoledronate. b) Dose-response curves for SaHepPPS inhibition by pyridinium bisphosphonates. c) Effects of chain length on SaHepPPS inhibition (log IC50) for 1-H analogs of zoledronate. d) Effect of chain length on SaHepPPS inhibition (log IC50) for zoledronate analogs. e) Lineweaver-Burk plot for SaHepPPS in the presence of 1 μM 5. F) Enzyme kinetics of SaHepPPS in the presence of 1 μM 5. Data points are shown as mean±SD, for duplicate experiments.