Table 3.
Physicochemical characterizations of PTX-loaded PEG-b-FTS micelles.
| Micelles | Mass ratio (mg: mg)a | Size (nm)b | PDIc | DLC(%)d | DLE(%)e | Stabilityf |
|---|---|---|---|---|---|---|
| POEG15-b-PFTS6 : PTX | 10: 1 | 32.8 ± 0.3 | 0.26 ± 0.01 | 4.6 | 51.1 | 5 d |
| POEG15-b-PFTS6 : PTX | 15: 1 | 32.8 ± 0.2 | 0.24 ± 0.02 | 4.3 | 68.7 | 8 d |
| POEG15-b-PFTS6 : PTX | 30: 1 | 37.8 ± 0.2 | 0.34 ± 0.03 | 2.8 | 87.4 | 12 d |
| POEG15-b-PFTS16 : PTX | 10: 1 | 115.6 ± 1.9 | 0.32 ± 0.04 | 8.2 | 90.5 | 9 d |
| POEG15-b-PFTS16 : PTX | 15: 1 | 113.9 ± 2.1 | 0.32 ± 0.04 | 5.4 | 85.9 | 13 d |
| POEG15-b-PFTS16 : PTX | 30: 1 | 130.6 ± 1.7 | 0.39 ± 0.03 | 3.1 | 96.7 | 23 d |
a
PTX concentration in micelles was kept at 1 mg/mL.
b
Measured by dynamic light scattering particle sizer.
c
PDI = polydispersity index.
d
DLC = drug loading capacity.
e
DLE = drug loading efficiency.
f
Data mean that there was no noticeable PTX precipitation during the follow-up period at 4 °C.