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. 2015 Nov 13;75(9):1667–1673. doi: 10.1136/annrheumdis-2015-207838

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

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Investigation of SI outcomes. Boxes in colour indicate the outcomes of interest and boxes in black indicate the reference population. Approach A examined the risks of sepsis and death after SI simultaneously; this approach accounts for possibly undetected but fatal cases of sepsis (see: objectives & methods). Approach B focuses on the mortality risk of sepsis. Overall mortality after SI was examined in approach C. All sensitivity analyses were applied in the setting of approach A. GEE, generalised estimating equations; SI, serious infection.