Table 3.

Overview of commonly reported serious adverse events

Serious adverse events	Tocilizumab exposure (N=417; 407.0 PYs)
	Patients, n (%)	Events, n	Rate/100 PYs
Serious infections	55 (13.2)	74	18.2
Bacterial pneumonia	10 (2.4)	12	2.9
Gastroenteritis	8 (1.9)	9	2.2
Bronchitis	4 (1.0)	6	1.5
Cellulitis	3 (0.7)	3	0.7
Sepsis	3 (0.7)	3	0.7
Herpes zoster	3 (0.7)	3	0.7
Influenza	3 (0.7)	3	0.7
Pneumocystis jirovecii pneumonia	2 (0.5)	2	0.5
Varicella	2 (0.5)	2	0.5
Macrophage activation syndrome	24 (5.8)	26	6.4
Serious infusion-related reactions	8 (1.9)	14	3.4

PYs, patient-years.