Table 3.
Subgroup analysis of circulating resistin levels and colorectal cancer.
| Stratification group | Data points (N) | Cases | Random effects | Heterogeneity | ||
|---|---|---|---|---|---|---|
| CRCs | Controls | WMD (95% CI) | I 2 (%) | p value | ||
| All studies | 11 | 965 | 1325 | 1.47 [0.78, 2.16] | 72 | <0.0001 |
| Study location | ||||||
| Western | 4 | 178 | 159 | 0.93 [−1.20, 3.05] | 83 | 0.0005 |
| Asian | 6 | 331 | 332 | 1.70 [1.03, 2.37] | 57 | 0.04 |
| USA | 1 | 456 | 834 | 0.50 [−0.52, 1.52] | — | — |
| Study design | ||||||
| Case-control | 10 | 509 | 491 | 1.84 [1.51, 2.18] | 70 | 0.0004 |
| Case-cohort | 1 | 456 | 834 | 0.50 [−0.52, 1.52] | — | — |
| Sample size | ||||||
| <100 CRC cases | 8 | 294 | 276 | 1.48 [0.38, 2.57] | 75 | 0.0002 |
| ≥100 CRC cases | 3 | 671 | 1049 | 1.42 [0.55, 2.28] | 74 | 0.02 |
| Blood sample | ||||||
| Plasma | 4 | 673 | 1043 | 0.59 [−0.39, 1.57] | 50 | 0.11 |
| Serum | 7 | 292 | 282 | 1.97 [1.18, 2.75] | 68 | 0.004 |
| Assay method | ||||||
| ELISA | 9 | 442 | 431 | 1.68 [0.95, 2.41] | 72 | 0.0004 |
| Multiplex immunoassay | 2 | 523 | 894 | 0.45 [−0.50, 1.40] | 0 | 0.78 |
| Study quality | ||||||
| Low (NOS score ≤ 5) | 7 | 329 | 312 | 1.69 [0.98, 2.41] | 62 | 0.01 |
| High (NOS score > 5) | 4 | 636 | 1013 | 1.22 [−0.33, 2.78] | 79 | 0.002 |
| Mean age, years | ||||||
| <60 | 2 | 66 | 67 | 1.15 [0.19, 2.11] | 38 | 0.2 |
| ≥60 | 9 | 879 | 1238 | 1.56 [0.65, 2.47] | 79 | <0.0001 |
| Not mentioned | 1 | 20 | 20 | 1.53 [0.45, 2.61] | — | — |
| Mean BMI, kg/m2 | ||||||
| <25 | 1 | 115 | 115 | 1.40 [0.64, 2.16] | 73 | 0.01 |
| ≥25 | 6 | 665 | 1026 | 1.83 [0.54, 3.12] | 79 | 0.0002 |
| Not mentioned | 4 | 185 | 184 | 1.03 [−0.14, 2.21] | 73 | 0.01 |