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Extracellular ROS production of HepK2 and HepK6 cell cocultures control (Co) or exposed to matriptase inhibitors (MI-432, MI-441, MI-460, or MI-461) using Amplex Red method. Results are expressed as mean values relative to controls ± SEMs. Significant differences in fluorescence intensities were found between control and MI-441-treated coculture groups (∗ p < 0.05, n = 4, in HepK2 and ∗∗ p < 0.01, n = 4, in HepK6 samples).
